Hazard determinations as specified at 29 cfr, part 1910. View product specific information, msds and references. Identification of the substancemixture and of the companyundertaking 1. Ofloxacin inhibits bacterial dna gyrase and topoisomerase iv, which haults dna replication and cell division. Ofloxacin may also be used to treat or prevent anthrax or plague serious infections that may be spread on. To help clear up your eye infection completely, keep using ophthalmic ofloxacin for the full time of treatment, even if your symptoms have disappeared. Ofloxacin has in vitro activity against a broad range of grampositive and gramnegative aerobic and anaerobic bacteria. Pharmacology, adverse reactions, warnings and side effects. Ofloxacin is thought to exert a bactericidal effect on susceptible bacterial cells by inhibiting dna gyrase, an essential bacterial. Material safety data sheet of ofloxacin abmole bioscience. Its commonly used as an eye drop to treat conjunctivitis pink eye and corneal ulcers the tablet form of ofloxacin is. Safety data sheet creation date mar2014 revision date 23jan2018 revision number 5 1.
Up to 400 mg may be given as a single dose, preferably in the morning. Floxinoz, taj products manufacturing, pharmaceutical. Sigmaaldrich offers a number of ofloxacin products. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Ofloxacin ophthalmic solution ofloxacin ophthalmic solution. Ofloxacin ophthalmic route side effects mayo clinic. Methods and materials for containment and cleaning up. Ofloxacin was first patented in 1982 european patent daiichi and received approval from the u.
It works by killing bacteria or preventing their growth. Ofloxacin c18h20fn3o4 cid 4583 structure, chemical names, physical and. Serious adverse reactions fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions e. Topical ofloxacin compared with gentamicin in the treatment of external ocular infection. Unnecessary use or overuse of any antibiotic can lead to. Ofloxacin,dextro ofloxacin certificate of analysis product name. Ofloxacin 200 mg tablets summary of product characteristics. In individual cases it may be necessary to increase the dose to. To keep the medicine as germ free as possible, do not touch the applicator tip to any surface including the eye.
Serum, urine and tear concentrations of ofloxacin were measured in 30 healthy women at various time points during a tenday course of treatment with ocuflox solution. Find patient medical information for ofloxacin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. First aid measures material safety data sheet material levofloxacin tablets 250 mg, 500 mg and 750 mg manufacturer lupin limited goa 403 722 india. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. It is a chiral molecule that inhibits pneumococcal cell walldegrading virulence factors. If you notice any other effects, check with your healthcare professional. The dosage range for adults is 200 mg to 800 mg daily. Ofloxacin is thought to exert a bactericidal effect on susceptible bacterial cells by inhibiting the essential bacterial enzyme dna gyrase, a critical catalyst in the duplication, transcription and repair of bacteria. Pdf topical ofloxacin compared with gentamicin in the. Novoofloxacin, tablet, oral, novopharm limited, 20040611. Formulation and evaluation of ofloxacin aqueous injection.
Ofloxacin is a broadspectrum, synthetic fluoroquinolone antibacterial agent for oral administration. However, this medicine will not work for colds, flu, or other virus infections. Ofloxacin has no effect on fertility, peri or postnatal development, and therapeutic doses did not lead to any teratogenic or other embryotoxic effects in animals. If inhaled if breathed in, move person into fresh air. Asymmetric metal free synthesis of fluoroquinolones by organocatalytic hydrogenation tetrahedron 2010, 66, 65656568. Uses advised against food, drug, pesticide or biocidal product use. The information contained in this data sheet represents the best information currently available to us. For research use only, not for human or veterinary use. Eye contact hold eye open and rinse slowly and gently with water for 15 20 minutes. It has a role as a dna synthesis inhibitor, an antiinfective agent and an antibacterial drug.
In case of burns quickly immerse affected area in cold water for at least 20 minutes. Nov 28, 2016 ofloxacin ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ofloxacin 20 mgkg, norfloxacin 40 mgkg, pefloxacin mesylate dihydrate 40 mgkgand ciprofloxacin 50 mgkg were administered by gavage. Call your doctor for medical advice about side effects. Ofloxacin is used to treat bacterial infections of the skin, lungs, prostate, or urinary tract bladder and kidneys. Ofloxacin is an oxazinoquinolone carrying carboxy, fluoro, methyl and 4methylpiperazino substituents. Ofloxacin is an antibiotic that can be used to treat infections of. Ofloxacin floxin side effects, dosage, interactions drugs. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Ofloxacin 82419361 buy and find out price and availability, msds, properties of tcis high quality specialty chemicals.
The dose of ofloxacin is determined by the type and severity of the infection. If a person vomits place them in the recovery position so that vomit will not reenter the mouth and throat. It will not work for other types of eye infections. Absorb solutions with finely powdered liquidbinding material diatomite, universal binders. Ofloxacin tablets prescription and dosage sizes information for physicians and healthcare professionals. This medicine is available only with your doctors prescription. When a new sds is obtained for a product, remove the earlier version and replace it with the new one, however, do not discard the older version. This compound is often given as a topical treatment for ocular and otic infections. Taj products taj pharmaceuticals product manufacturer pharmacological products in india,tablets,exporter india,capsules,injections,manufacturing of pharmaceuticals,manufacturer,composition,drugs,formula,producing product,msds,coa, pdf,doc chemical api method according to the present product invention supplier product. The mean serum ofloxacin concentration ranged from 0. Ofloxacin belongs to the class of drugs known as fluoroquinolone antibiotics. Ofloxacin is a fluoroquinolone florokwinolone antibiotic that fights bacteria in the body. College of pharmacy, chitradurga, karnataka india abstract ofloxacin is a synthetic fluoroquinolone broad spectrum anti microbial agent used in the treatment of bacterial.
Like other fluoroquinolones, ofloxacin inhibits dna gyrase and topoisomerase iv. Ofloxacin may cause live bacterial vaccines such as typhoid vaccine to not work as well. Ofloxacin is an antibiotic useful for the treatment of a number of bacterial infections. All quotes are valid for 30 days unless otherwise stated. Ciprofloxacin binds to and inhibits bacterial dna gyrase, an enzyme essential for dna replication. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Ofloxacin belongs to a class of drugs called quinolone antibiotics. Other uses, along with other medications, include treating multidrug resistant tuberculosis. Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a secondgeneration fluoroquinolone. Ofloxacin is bactericidal at concentrations equal to or slightly greater than inhibitory concentrations.
You may report side effects to the fda at 1800fda1088. Ofloxacin is also sometimes used to treat other types of infection, including legionnaires disease type of lung infection, certain sexually transmitted diseases, infections of the bones and joints and of the stomach and intestines. When beeswax is heated above the human body temperature and depending on the length of time the heated beeswax is exposed to the skin it will cause the skin to burn. The mean halflife, determined in the dialysisfree interval t1 2.
Ciprofloxacin is a synthetic broad spectrum fluoroquinolone antibiotic. This agent is more active against gramnegative bacteria than grampositive bacteria. Ofloxacin solution ophthalmic ocuflox side effects. This medication treats only bacterial eye infections. Ofloxacin belongs to a group of antibacterial medicines known as fluoroquinolones. Ofloxacin is an antibiotic drug used to treat bacterial infections. The safety data sheets sdss are intended to provide health, safety and environmental information for the people handling these products. Identification of the substancemixture and of the companyundertaking product name. Ofloxacin cas 82419361 scbt santa cruz biotechnology. Ofloxacin, like other 4quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial dna synthesis, rather than cell wall or protein synthesis 2. Admet data is predicted using admetsar, a free tool for evaluating chemical admet properties. Following is a list of allergan products for which material safety data sheets msds are not required. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ofloxacin fluoroquinoloneantibiotic 82419361 sigma.
Ofloxacin tablets, tablet, oral, aa pharma inc, 19980217, 20160802. Ofloxacin has been shown to convert lyta from the inactive eform to the active cform. The mean halflife, determined in the dialysisfree interval t12. A synthetic fluoroquinolone antibacterial agent, it inhibits the supercoiling activity of bacterial dna gyrase, halting dna replication. By comparison, dermal levofloxacin concentrations in human subjects receiving 750 mg of levofloxacin averaged approximately 11.
Ofloxacin is also used to treat pelvic inflammatory disease and chlamydia andor gonorrhea. Hazards identification general advice consult a physician. Show this safety data sheet to the doctor in attendance. Ofloxacin is a fluoroquinolone antibiotic targeting grampositive and gramnegative bacteria.
Maximum serum ofloxacin concentrations after ten days of topical ophthalmic dosing were more than times lower than those reported after standard oral. Ofloxacin floxin, ocuflox is a moderately priced drug used to treat certain types of bacterial infections. Ofloxacin is a second generation fluoroquinolone antibiotic. Ofloxacin is an antibiotic prescribed to treat pneumonia, bronchitis, staph infections, stds gonorrhea, chlamydia, urinary tract infections, and prostate infections caused by e. Floxin ofloxacin tablets tablets is a synthetic broadspectrum antimicrobial agent for oral administration. Nursing mothers in nursing women a single 200 mg oral dose resulted in concentrations of ofloxacin in milk which were similar to those found in plasma. Ciprofloxacin is a second generation fluoroquinolone antibiotic that is widely used in. Chemically, ofloxacin has three condensed 6membered rings made up of a fluorinated carboxyquinolone with a benzoxazine ring. Generic ofloxacin is covered by most medicare and insurance plans, but some pharmacy coupons or cash prices could be lower. Other side effects not listed may also occur in some patients. Generally, individual doses should be given at approximately equal intervals. Qualitative and quantitative composition each tablet contains 500 mg of ornidazole. Call a poison control center or doctor for treatment advice.
Find patient medical information for ofloxacin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Keep the product away from drains or water courses. Ofloxacin is a fluorinated 4quinolone which differs from other fluorinated 4quinolones in that there is a six member pyridobenzoxazine ring from positions 1 to 8 of the basic ring structure. Do not have any immunizations vaccinations while using this medication unless your doctor tells you to.
Ofloxacin oral route description and brand names mayo. White to slightly yellowish, cylindrical, biconvex film coated tablets. This product is available in the following dosage forms. Ofloxacin study group article pdf available in british journal of ophthalmology 7612. Ofloxacin tablets ofloxacin dose, indications, adverse. If swallowed, seek medical advice immediately and show the container or label. Capitals indicate lifethreatening, underlines indicate most frequent. Serum and milk were obtained from 10 women simultaneously at 2, 4, 6, 9, 12, and 24 h after ofloxacin. Formulation and evaluation of ofloxacin aqueous injection 1, t.
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